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ARISTOLOCHIC ACIDS
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DeCS
Descriptor
English
:
Aristolochic Acids
Descriptor
Spanish
:
Ácidos Aristolóquicos
Descriptor
Portuguese
:
Ácidos Aristolóquicos
Tree Number:
D02.455.426.559.847.723.089
D02.640.139
D04.615.723.089
Definition
English
:
Nitro-phenanthrenes occurring in
ARISTOLOCHIACEAE
and other
plants
. They derive from stephanine (
APORPHINES
) by oxidative ring cleavage. The nitro group is a reactive alkylator (
ALKYLATING AGENTS
) that binds to biological macromolecules. Ingestion by
humans
is associated with nephropathy (
NEPHRITIS
). There is no relationship to the
similar
named aristolochene (
SESQUITERPENES
).
History Note
English
:
2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
37310
Unique Identifier:
D034341
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS